What is marijuana?
Marijuana (cannabis) is a plant scientifically named cannabis sativa that has been used by humans for centuries in clothing, food, and reportedly by the Chinese as a means of communicating with spirits.
Today, marijuana is grown in temperate climates, its hemp is used in clothing and building materials, while its fruit is used in food and chemicals. The more temperate the climate, the fewer resins (psychoactive alkaloids) are found in it. On the other hand, it contains a large amount of resins when grown in tropical countries.
Marijuana is the most commonly used illicit drug and the illicit drug that new users are most likely to try.
Cannabis or (marijuana) contains THC ( Tetrahydrocannabinol ) as the main active ingredient that makes you feel high as it is a psychoactive alkaloid. It also contains other chemicals that affect how the body works, such as sterols, amino acids, volatile oils, and oxidase enzymes.
Most people smoke the dried leaves, flowers, stems, and seeds of the plant. Marijuana can also be mixed into food, brewed as a tea, or inhaled with a vaporizer. No matter how it gets into your system, it affects almost every organ in your body, including your nervous system and immune system.
How does marijuana affect the human body?
THC produced in the body after using marijuana activates ” cannabinoid reactive receptors” leading to the development of marijuana abuse symptoms including physical relaxation, hyperphagia (increased appetite), increased heart rate, decreased muscle coordination, conjunctivitis, easy pain control and hallucinations. Marijuana also stimulates the amygdala , giving the user a sense of novelty to everything the user encounters through an improvement in sensory activity. For the same reason, heavy users have a down-regulation of their cannabinoid receptors , leaving them feeling bored when not taking the drug.
Marijuana abuse can cause short-term memory loss due to its effects on the GABA neurotransmitter.
Short-term use of marijuana can increase your heart rate by 2x for up to 3 hours. That’s why some people get heart attacks right after using marijuana. It can increase HHC kaufen bleeding, lower blood pressure, and also affect your blood sugar.
Long-term effects of use can include chronic bronchitis, chronic obstructive pulmonary disease, increased progression of HIV (Human Immunodeficiency Virus) and breast cancer, and worsening of mental illness. Tolerance develops rapidly in users and withdrawal has been observed.
Cannabinoids and related drug abuse
All medications have side effects. Some of these have only been deemed legal for certain uses due to the possibility of drug addiction. Cannabinoids are one of these highly regulated drugs. It is important that you understand more about the effects and how devastating it can be when misused. There are several factors to consider to ensure safety .
Overview:
Cannabinoids are described as a class of terpenophenolic compounds found in cannabis and commonly found in the immune and nervous systems of animals. The broader description of cannabinoids refers to a group of substances structurally related to THC or tetrahydrocannabinol or associated with cannabinoid receptors.
The chemical description encompasses a number of unique chemical classes: the nonclassical cannabinoids , the classical cannabinoids , which are structurally linked to THC, the eicosanoids, which are linked to the endocannabinoids , the aminoalkylindoles , quinolines , arylsulfonamides , and 1,5 -diarylpyrazoles. Other compounds bind to cannabinoid receptors but are not included in these standard groups.
The term:
The term cannabinoids comes from the unique group of secondary metabolites found in the cannabis plant. These trigger the unique pharmacological effects of the plant. There are 3 main types of cannabinoids today, namely endogenous cannabinoids , phytocannabinoids and synthetic cannabinoids . Endogenous cannabinoids are formed in the body of animals and humans. Phytocannabinoids are present in the cannabis plant. Synthetic cannabinoids are similar compounds made in laboratories.
About the receptors:
It was previously thought that cannabinoids could produce their own behavioral and physical effects through non-specific activities with cell membranes, rather than just associating with specific receptors. The first cannabinoid receptors were discovered in the 1980s. The receptors are present in animals such as mammals, birds and reptiles. The two known types are called CB1 and CB2.
Type 1 and 2:
Cannabinoid receptors type 1 or CB1 are mainly located in the brain, specifically in the hippocampus, basal ganglia and limbic system. These are located in the cerebellum and in both male and female reproductive systems. Due to the absence of the receptors in the medulla oblongata, there is a reduced risk of cardiac or respiratory failure. The anticonvulsant and euphoric effects of cannabis are believed to be triggered by CB1 receptors.
CB2 receptors are almost exclusively found in the immune system. Most of the density is in the spleen. These are generally only found in the peripheral nervous system. These appear to trigger the therapeutic and anti-inflammatory effects of cannabis.
About Phytocannabinoids , Endocannabinoids and Synthetic Compounds: Phytocannabinoids are not completely water soluble. However, these are soluble in non-polar organic solvents, alcohols and lipids. Water-soluble phenolate salts can be formed under strongly alkaline conditions.
Endocannabinoids are formed in the body and trigger the receptors. Scientists began searching for the receptor’s endogenous ligand after the first receptor was discovered. New compounds are not associated with natural cannabinoids .
Synthetic cannabinoids can be very useful in tests to find out more about the correspondence between the activity of the cannabinoid compounds and the structure. Molecules of cannabinoids are modified and systematized to learn more about the various relationships
The effects:
Neurotransmission can be restricted by cannabinoids . The effects of the drugs may change depending on the location. Depending on the dosage and extent, the functions of the affected brain region change. Some of the changes the user may experience include loss of motor coordination and control, emotional changes, changes in memory and cognitive ability, analgesia, nausea and vomiting.